Interactive materials are materials which can "sense" their environment, and that can alter their behavior in a response to a stimulus or a change in their environment. In our group we design, fabricate, and study the properties of interactive materials that contain chemical information for performing a specific task or function that is coded in their chemical structure. In particular, we are interested in synthesis and fabrication of polymer fibers that can hold chemical and physical information, and study how can this information be used for folding these one-dimensional fibers into three-dimensional structures, and how can a specific design lead to selective binding and to self-assembly. Using tools from thermodynamic and from Information Theory, we explore the underlying principles that determine the behavior of programmable materials. We also study the use of such materials for fabrication of microelectromechanical systems (MEMs) and for medical applications including tissue engineering and smart drugs release mechanisms. In our lab, we employ a variety of fabrication techniques including lithography, electrohydrodynamic co-jetting, and deposition methods. In addition, we make use an array of microscopy and spectroscopy techniques for characterization and manipulation of these systems and utilize a variety of computational and theoretical tools for modeling, analysis, and understanding the characteristics of such materials.